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Reduced drug uptake serves as a primary line of defense, even before other resistance mechanisms develop

Gene variants are what allow each of us to be unique

In this mitotically active cell, interkinetic migration of the nucleus occurs during the S phase of the cell cycle, and its self-renewal can be symmetrical, generating two daughter cells with the characteristics of the initial cell (neural stem cell), or asymmetric, generating a new radial glia and a cell that can be differentiated (progenitor cell of a cell subtype) (Alvarez-Buylla et al., 2001

A maintenance dose is the dose given regularly over the long term to maintain the desired effect after the initial response has been achieved