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doi: 10.1074/jbc.M117.814244
Excessive Fe 2+ impairs the function of pancreatic cells and liver cells through oxidative stress and mitochondrial injury, leading to insulin resistance and affecting NAFLD development ( 2+ , elevates ROS levels, and leads to ferroptosis ( in vitro and in vivo ( Intervention effects of herbs or herbal extracts in regulating ferroptosis on non-alcoholic fatty liver disease Currently, there is no agreed standard or definitive effective drugs for the treatment of NAFLD

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Other groups including ICI, (later AstraZeneca), Abbott- Takeda and Hoechst AG, (later Aventis) also developed depot formulations of their respective LH-RH agonists, goserelin, leuprolide, and buserelin consisting of microcapsules or implants in poly (lactide-glycolide) or other polymers administered once a month 3
