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Description
The MKN45 tumor cells were used to establish the tumor model

Acyl-CoA Synthetase 1 Is Required for Oleate and Linoleate Mediated Inhibition of Cholesterol Efflux through ATP-Binding Cassette Transporter A1 in Macrophages

However, it can also be the result of low B6, low folate, renal failure, or hypothyroidism

It will be essential to identify combination treatments which would convert CDK4/6-inhibitors from the cytostatic compounds to cytotoxic ones, and would unleash the killing of tumor cells
