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NP-conjugated miRNA was used for inhibition of chemokines CCL2, 5, 8, and 9 and CXCL9 expression in VECs, and, thus, for ASCVD therapy

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In addition, compound 968 (a GLS-1 inhibitor) was cytotoxic for the del(11q) CLL cells, in which ROS levels were increased upon GLS-1 inhibition

For other parenteral routes such as subcutaneous and intramuscular injections, the bioavailability may still be close to 100 % for most therapeutic drugs (F = 0.751), since little or no significant metabolism of the drug occurs in the skin or muscle and these small molecules (MW 0 min) compared to the intravenous route