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Age-Related Changes: Older adults often produce less stomach acid, which can hinder B12 absorption from food
ERS can activate the expression of Ca 2+ release channels on inositol 1,4,5-trisphosphate receptors (IP3R), thereby mediating the release of ER-Ca 2+

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Moreover, these risks are further potentiated if both the APAP-consuming mother and her child exhibited GSTM1 polymorphism [101]
