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However, peripheral antagonist injections do not have consistent effects, due in part to biphasic effects at different doses (Woolverton, 1986
doi: 10.1038/oby.2010.147
Bone histomorphometric analysis Dynamic histomorphometry was performed to assess mineralizing surface to bone surface (MS/BS), mineral apposition rate (MAR), and bone formation rate normalized to bone surface (BFR/BS) [61]
Although antioxidant defense mechanisms [glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase (Cat)] work to neutralize ROS, their capacity is often overwhelmed in chronic pain states
