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This extends the practical utility of each vial compared to single-dose formulations that must be discarded immediately after opening

10.1073/pnas.2022830118 93 ZhangZ.ChenX.GaoS.FangX.RenS

PMID 40544433.

Surgery is generally reserved for cases with progressive neurological deficits, cauda equina syndrome (a surgical emergency), or persistent symptoms despite 6 to 12 months of conservative treatment
