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In addition, pharmacokinetic properties such as drug-likeness, gastrointestinal absorption, and blood brain-barrier (BBB) permeability are important to consider when evaluating its ADME profile (Daina et al., 2017)

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Dysfunction of the gut microbiota not only causes a variety of gastrointestinal diseases, such as diarrhea, constipation, and enteritis, but can also induce chronic diseases, such as obesity, cardiovascular disease, diabetes, and metabolic syndrome (Marchesi et al., 2016