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The IGF-1R, which is ubiquitously expressed across nearly all cell types in the organism, consists of two and two subunits linked by disulfide bonds (Muraguchi et al., 2019)

Nrf2/Keap1/ARE signaling: towards specific regulation

At endpoint A, the gene encoding NFIC is upregulated in the SEV group compared to controls (contrast 2), suggesting an important role for this TF in the transcription of inflammatory genes in severe COVID-19
