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Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes
doi: 10.1016/j.semcancer.2018.07.009 40 ZhaoDLiWHanZWangZLiDLiW
Clinical trials have shown that the LXR agonist, T0901317, and the PPAR agonist, rosiglitazone, activate ABCA1/G1 expression, promote cholesterol efflux, increase HDL levels, and reduce plaque volume [159,161]
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