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Description
5-Amino-1MQ inhibits the NNMT enzyme, which increases intracellular NAD+ availability and reactivates mitochondrial fat oxidation pathways the weight loss occurs through increased cellular energy expenditure without reducing appetite

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MTHFR mutations impact the bodies ability to use vitamin B12

Some researchers have conceptually explored combining both strategies for potentially synergistic effects on intracellular NAD+ levels, though no published data exists for this specific combination