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Notably, despite the induction of pain following acute TRPV1 activation by agonists such as capsaicin, prolonged/repeated stimulation has been shown to lead to receptor desensitization with analgesic effects (Gao et al., 2024)
(PubMed) Wen SW, White RR, Rybak N, et al
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Ibuprofen Protects Dopaminergic Neurons Against Glutamate Toxicity In Vitro
