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Luo et al., Epigenetic suppression of PGC1 (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas

Kaul and his co-workers estimated the ILD prevalence and incidence ranges in heterogeneous studies and they found the incidence of ILD ranged from 1.0 to 31.5 per 100,000 population and prevalence ranged from 6.3 to 71 per 100,000 population, annually (Kaul et al ., 2021)

The median PFS was 1.0 (95% CI, 0.91.1) month, and OS was 9.8 (95% CI, 8.411.2) months

(3) Analyze the binding modes of inhibitors, examine the interactions that facilitate inhibitor binding, and identify key binding residues or regions of the inhibitors