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They are linked to the endoplasmic reticulum (ER) by a multiprotein complex called the ER-mitochondria encounter structure (ERMES), which is unique in the fungal kingdom

Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl2 expression after focal cerebral ischemia

Prakobwong et al., 2011)

Integrin 51FAK/Src signaling is activated by alteration in the ECM composition, which in turn enhances the motility, while lymphocyte infiltration is restricted by the dense collagen network, adding another layer of immunosuppression (113)
