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The primary role of the BBB is to control the flow of substances between the blood and the central nervous system according to the physiological needs of the brain

Fatigue or feeling cold during fast weight loss Fewer cravings for alcohol, snacks, or junk food (commonly reported) When to Slow Down or Stop Vomiting that does not stop within 24 hours Severe upper abdominal pain that wraps around to the back Yellowing of skin or eyes Severe dehydration signs (dizziness, very dark urine, racing heart) Rapid weight loss over 2 lb per week sustained for many weeks (lean tissue loss risk) 13

Typical courses run 46 weeks for acute injuries

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