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Description
Simeone Radiology.2022
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Hepatocellular Carcinoma Cells
Figure 7 In the phenylpropanoid biosynthesis pathway, two genes encoding phenylalanine ammonia-lyase ( PAL ) and 4-coumarate-CoA ligase ( 4CL ) were upregulated, four genes encoding -glucosidase were upregulated and one gene was downregulated, nine genes encoding peroxidase ( POD ) were upregulated and seven genes were downregulated, and the metabolites p-coumaric acid and ferulic acid were upregulated under drought stress
Mechanism of action: These treatment modalities inhibit the COMT enzyme, reducing catecholamine levels, including norepinephrine and dopamine degradation
