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Besides producing light sedation without respiratory depression, dexmedetomidine has anxiolytic and sympatholytic properties that reduce autonomic hyperactivity, qualities that support its use in AWS

19,20,50, 58, 59 Internal mechanisms include the production of their own antioxidant enzymes like SOD and CAT and synthesis of antioxidant metabolites such as folate and glutathione

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255,256 Furthermore, tazemetostat is being investigated as a single agent for malignant mesothelioma, with ongoing efforts to refine biomarkers for its activity in malignant pleural mesothelioma