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In the embryonal stage, a wide-open communication exists between the yolk sac and primitive gut

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Under normal physiological conditions, the BBB separates the central nervous system from the peripheral vascular system, thereby maintaining stable iron levels within the brain

Additionally, SFN combined with 5-aza-2-deoxycytidine and trichostatin A significantly reduced the CpG methylation levels in the NRF2 promoter region and inhibited the protein expression of DNA methyltransferase 1 (DNMT1), thereby promoting NRF2 expression, which may play a preventive role in colon cancer [151]