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MOTS-C , for example, is a mitochondrial-derived peptide that influences energy metabolism

It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism

If youre looking for alternatives, its worth understanding options like liposomal B12 as a potential alternative