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The mechanism of EtOH-induced depletion of GSH may involve the direct conjugation of GSH with acetaldehyde (AcH), the reactive intermediate of EtOH oxidation [48, 49]

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In order to better appreciate the activity of glutathione peroxidase in seminal plasma, it would be interesting to associate the enzyme activity with those of glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT), which are the main enzymes involved in the metabolism of glutathione peroxidase