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AHK-Cu (Ala-His-Lys-Cu) is a related copper tripeptide found in human plasma that shares the His-Lys copper-binding motif but substitutes alanine for glycine at the N-terminal position, resulting in a slightly different copper coordination geometry and a distinct (though overlapping) gene expression modulation profile

Some people may notice stomach discomfort or indigestion, which is another reason the tablets are usually taken after meals

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Strikingly, GPx4 mRNA levels remained unchanged under ethanol treatment, while GPx4 protein expression was upregulated in both ethanol-exposed AML12 cells and primary hepatic cells (PHC) (Fig