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Both HIV and Ebola viruses share with SARS-CoV-2 the common feature that they are coated viruses, i.e., covered by a phospholipid pericapsid, therefore they are expected to respond more effectively to the action of O 2 -O 3 therapy, while the response of viruses with protein capsid is variable (Bocci, 1996)

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Indeed, melatonin is highly permeable to cell membranes and easily crosses the bloodbrain barrier 51 , ensuring a good therapeutic profile for brain diseases, and is also able to accumulate into mitochondria, probably via GLUT/SLC2A and PEPT1/2 carriers 52,53