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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction

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The authors sincerely thank Professor Graham Rook (University College London, United Kingdom) for discussions on his Old Friends Hypothesis and critical reading of the manuscript, and Professor Hanna Kmita (Adam Mickiewicz University, Poznan, Poland) for a critical reading of the manuscript and helpful suggestions for its improvement