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Read review Dihexa for Migraine & Chronic Migraine The May 2024 NICE TA973 atogepant (Aquipta, AbbVie) approval, the rimegepant / erenumab / galcanezumab / fremanezumab / eptinezumab CGRP pathway, 2025 chronic-migraine hippocampal atrophy & accelerated brain ageing research, the Tanure BDNF-elevated-in-attack paradox, NICE NG150, and the ~10 million UK migraine population

Potential side effects include: Skin irritation (with topical use) Increased risk of infections (with oral use) Headaches and fatigue Increased cholesterol levels Potential risk of blood clots (with long-term oral use) Patients should always consult a dermatologist before starting treatment with JAK inhibitors to weigh the benefits against possible risks

Also, in contrast to glutamate, aspartate cannot sustain its own uptake in cultured astrocytes by oxidative metabolism (Peng et al., 2001), as it should have been able to do in order for the subsequent oxaloacetate-to-malate reduction suggested by LaNoue et al

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
