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Traditionally injected, both TB-500 and BPC-157 have seen recent advances to increase their stability and oral bioavailability, potentially augmenting their therapeutic applications and marketing appeal [7, 8]

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Mechanical and chemical stimulation of the gut by the passage of a bolus, pressure due to distension or microbial mediators, nutrients, toxins, or irritants activates the mechano- and/or chemosensory systems of the intestinal epithelium to initiate digestive and defensive reflexes (409, 413, 423426)