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Conversely, [Thrombin] low promoted L-type voltage gated calcium channel (L-VGCC), metabotropic glutamate receptor 5 (mGluR-5), and intracellular Ca 2+ store-dependent LTP, which required aPC and the activation of the Endothelial Protein C Receptor (EPCR, detected on astrocytes and neurons) (Maggio et al., 2013c)

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However, luteolin targets lung fibrosis through multiple pathways

NF-B:Nuclear factor kappa-B