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It was found that TCP1 (also known as CCT1 subunit), which is overexpressed in HCC, can act as an upstream mediator of Wnt7b and increase Wnt7b expression, thus activating this pathway and enhancing the proliferation and metastasis of HCC cells (127)
Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically
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