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Although no single biological or behavioral abnormality will characterize all individuals with MDD, the identification of an abnormality associated with MDD may open the door to identifying a relatively biologically homogeneous subgroup that demonstrates a larger treatment response to interventions that target the specific abnormality 11

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To address this issue, the scientific community is actively exploring multiple strategies, including the development of novel antibiotics, optimization of existing ones, discovery of antimicrobial peptides, and combination therapies