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Description
Yearly monitoring of B 12 status and suitable adjustment of the supplementation dose is recommended

*B vitamins* are crucial for energy metabolism

If you're getting a cyanocobalamin (also present in oral and sublingual B12) that's more likely to cause negative reactions
Pyridoxine also antagonizes the effects of levodopa when levodopa is used without a dopa-decarboxylase inhibitor (such as carbidopa)