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We have also tested whether redox-sensitive TRP channels including TRPC1, TRPM7 and TRPV1 gene expression in C6 was changed by [GSH] I manipulations as they can produce cell adaptations to oxidative environment ( 2+ rise in these cells whatever the treatment

Under low glucose conditions, glutamate dehydrogenase 1 (GDH1) phosphorylats and interacts with p65 and IKK of the NF-B signaling pathway, and -ketoglutarate produced by GDH1 binds to and activates IKK and NF-B signaling, leading to compensatory glucose uptake by upregulating GLUT1 18

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doi: 10.1371/journal.pone.0094208 [DOI] [PMC free article] [PubMed] [Google Scholar] 159.Bonovas S, Fiorino G, Lytras T, Nikolopoulos G, Peyrin-Biroulet L, Danese S