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(2008) The Catalogue of Somatic Mutations in Cancer (COSMIC)

The presentation included clinical history and autopsy findings [the patient] had been for many years troubled with flatulency and complaints in the bowels, attended with costiveness, a quick pulse and an irregular intermittent feverHe especially complained of wind and great costiveness, and about two to three hours after eating, of excessive pain in the bowels

Further results with isatuximab and daratumumab in NDMM with combination regimens such as bortezomib-lenalidomide-dexamethasone or carfilzomib-lenalidomide-dexamethasone are awaited with interest (NCT03319667, NCT03617731, NCT04483739, NCT03710603, NCT03652064)

Researchers propose this mechanism could show selective toxicity toward cancer cells because: Tumor cells often lack catalase and other peroxide-neutralizing enzymes Cancer microenvironments contain elevated labile iron levels Normal cells maintain robust antioxidant defenses Clinical Trial Evidence Recent Phase II trials investigating vitamin C injections in cancer treatment have reported early signals that researchers describe as promising, though the evidence remains preliminary: Pancreatic Cancer Study: In a randomized Phase II trial of 34 patients with stage 4 metastatic pancreatic cancer led by Joseph Cullen at the University of IowaPharmacological ascorbate in combination with gemcitabine and nab-paclitaxel published in Redox Biology (2024)participants who received 75 grams (75,000 mg) of IV vitamin C three times weekly alongside standard chemotherapy reached a median overall survival of 16 months, compared with 8.3 months for chemotherapy alone