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Mitochondrial dysfunction induces an imbalance between oxidation and antioxidation, mitochondrial DNA (mtDNA) damage, mitochondrial dynamics dysregulation, and changes in mitophagy

doi: 10.1001/jama.2020.12839 116 GeorgievaEAnanievJYovchevYArabadzhievGAbrashevHAbrashevaDet al

We further determined that Norleual-AngIVs mechanism of action as a Met antagonist is by blocking HGF dimerization which, as indicated above, is a prerequisite to binding and activation of the Met receptor [82,83]

We identified the enriched de novo motifs across the whole genomic regions using the findMotifsGenome.pl function of HOMER (Heinz et al., 2010) (parameter: -size 500 -len 8,10,12 -mask -dumpFasta)