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Most stem cell therapy studies and clinical research report encouraging early results
Downregulation of circ-BGN significantly increases the levels of lipid ROS, MDA, and Fe 2+ , inhibits GPX4 activity, and leads to the inhibition of activity in breast cancer cells (Wang et al., 2022a)
Delivered under appropriate clinical monitoring
Iron-driven oxidation of dopamine results in the generation of 6-OHDA, which specifically inhibits mitochondrial complexes I and IV, leading to mitochondrial dysfunction (120)
