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In a 42-year-old woman with chronic fatigue and a serum vitamin B12 (cobalamin) level of 275 pg/mL, is intramuscular B12 injection therapy indicated?

As expected, the intra-chain salt bridge between residue 28 and the C-terminus is seen in all L-peptides, but it is formed in the DRI-peptides only for the K28E mutant

4 If vitamin B12 is lyophilized, such as in some forms of methylcobalamin, the medication should be refrigerated after mixing
