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That was a game-changing moment that sent me down a 25-year rabbit hole of personal experimentation with hormones, peptides, and therapeutic compounds
Interestingly, in the context of the transgenic mice expressing the mutant human B-crystallin, heterozygous knockout of Nrf2 lessened reductive stress decreasing the expression of the enzymes involved in GSH biosynthesis and recycling, resulting in a decrease in GSH concentration and the GSH/GSSG ratio
Yet few people realize that its levels naturally decline with age, stress and poor nutrition
