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Has it spent time at room temperature beyond the allowed window

Their successful translation ultimately depends on in-depth analysis of their mechanisms of action, the establishment of precise treatment strategies, and comprehensive evaluation of efficacy, safety, and cost-effectiveness

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For example, melanoma cells may shift from a GPX4-dependent ferroptosis resistance mechanism to reliance on alternative pathways such as FSP1-mediated lipid peroxide detoxification, thereby evading ferroptotic cell death (159, 160)