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However, the findings have been inconsistent with partly modest sample sizes (16)
Based on the available evidence and clinical expertise, the committee evaluated and determined the certainty of the evidence and the levels of recommendations
However, the expression trends of cdk4 , cdk6 , e2f1 , and rb1 in many other cancers were inconsistent, indicating that this signaling pathway may regulate the cell cycle by crossing with other signaling pathways, and CDK4/6 inhibitor combination therapies may lead to considerable antitumor effects in these cancers (Fig
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