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There was a positive trend in the Composite SLE Responder Index in the Intention-to-treat (ITT) cohort, and post-hoc analysis showed that the BILAG secondary endpoint was met for a number of subgroups dosing levels, including low or no steroids, seropositivity, and patients with 2 grade BILAG improvement

Vitamin B12 deficiency disrupts the methionine cycle, inducing hyperhomocysteinemiaa condition linked to oxidative stress and mitochondrial dysfunction in granulosa cells

Presently, the drugs available for treatment, including crizotinib or erlotinib, are tyrosine kinase inhibitors (TKIs) for cancer treatment (primarily lung adenocarcinoma), exhibiting EGFR mutations or EML4-ALK fusions

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