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Signal integration is accomplished by the assembly of cytosolic pattern recognition receptors (PRRs), including nucleotide oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, NLRC4, absent in melanoma 2 (AIM2), and pyrin, and activation of caspase-1

In contrast, in mice administered with the ROS-responsive P-Mn/TI@mHSA, protein NPs exhibited not only a markedly robust signal but also a more widely distributed pattern within the plaques

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