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Description
Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine
DREADDs with different coupling properties can be expressed in a cell type-specific fashion, for example by generating transgenic mice or by using virus-based delivery techniques
it goes where it's needed
Currently, the drug has been in phase II clinical trial (ClinicalTrials.gov:NCT01810705)
