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Future studies should prioritize defining the precise abundance threshold of Akkermansia muciniphila that balances its beneficial and deleterious effects on the intestinal barrier, investigating the molecular mediators (e.g., specific metabolites or surface proteins) that underpin its dual regulatory role, and developing targeted interventions (e.g., precision probiotics or microbiota modulators) to sustain its homeostatic levelswith the goal of ultimately mitigating OA progression via the gut-joint axis

When activated, these receptors trigger intracellular signaling cascades involving cAMP elevation, protein kinase A activation, and hormone-sensitive lipase stimulation, ultimately leading to triglyceride breakdown and fat mobilization

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