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The frequency of B-12 injections depends on the severity of the deficiency and individual health needs

The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2

In summary, this study demonstrated an improvement in pain with a vitamin supplementation regime inclusive of B12 but did not show improved efficacy with addition of folate [31]

Children may be given a total of 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance