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In triple-negative breast cancer, its inhibitor DMOCPTL induced ferroptosis of cancer cells by the ubiquitination of GPX4 of via regulating the activity of EGR1 [155]

Inflammation is a consequence of alpha-synuclein aggregation via an activation of microglia 9 , which, in a prolonged inflammatory state, can result in neurodegeneration

On the other hand, its high reactivity also contributes to the uncontrolled removal of electrons, which underlies pathological cell damage through the propagation of highly reactive oxygen-containing molecules

2.3 Cell culture and cell viability assay The MDA-MB-231 cells (procured from Warner Bio, Wuhan, China) were cultured in Dulbeccos modified Eagle medium, high glucose (Biosharp, Beijing, China), supplemented with 10% (v/v) fetal bovine serum (FBS) (Meilun Bio, Dalian, China) and 1% penicillinstreptomycin (P/S) (Tianhang, Shanghai, China)