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When TLR4 was depleted in mice, smaller intima-media aorta thickness was observed than in normal mice (21)
Dependent on protein purity, pooled eluates were either dialyzed immediately or further purified using anion exchange chromatography
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However, HDL-induced cell signaling through binding to glycoprotein IIb/IIIa on the surface of platelets was reported to activate phospholipase C (PLC) and PKC, thus leading to flux through the Na+/H+ antiport system (717)
