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Lastly, our group and others have implemented epigenetic manipulation in the form of pharmacological DNA hypomethylation to generate iTregs of defined phenotype and stable regulatory character [41,42,43,44]

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Mechanistically, this antitumor action of AC was achieved through inhibition of NF-B/matrix metalloproteinase-9 (MMP-9) signaling, Bcl-2, and Bcl-xL, in addition to augmentation of Bax (Zhang and Yuan 2018)