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Betaine was shown to suppress NLRP3 inflammasome activation and IL-1 production in the liver of diabetic mice by inhibiting insulin-induced activation of the FoxO1 transcription factor, leading to the activation of thioredoxin and hence suppression of ROS production in hepatocytes (Kim et al., 2017)

Ethics statement The studies involving humans were approved by The Ethics Committee of Weifang Peoples Hospital

Contraindications Pregnant or nursing mares seek veterinary guidance before use

The neuromuscular junction (NMJ) is the point of contact between neurons and muscle cells that allows neural signals to be transmitted to the muscle, triggering muscle contraction