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or degree of disability or dependence with daily tasks (4 trials) (102)
Additionally, the hypoxic microenvironment within tumors can induce the expression of HIF-1, which promotes EMT and activates survival pathways, thereby contributing to chemotherapy resistance (68)
The latter comparisons inferred the Sham D2 response was independent of radiation and was likely due to a delayed stress response
Management of these pigmented lesions generally does not require intervention unless there is an aesthetic concern or a need to confirm the benign nature of the pigmentation
