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A 2016 study published in Nature Scientific Reports showed GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers unlike other copper compounds

Ringo et al

Internalization has also been widely considered as the first step in receptor recovery from desensitization, leading to re-insertion of nondesensitized/reactivated receptors in the plasma membrane