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genetics infections physical or emotional stress food allergies injury or damage to the tissues of the mouth hormonal changes, such as those experienced during menstrual cycles, pregnancy, and menopause nutritional deficiencies, such as low iron, vitamin B12, and folic acid blood disorders, such as Sutton Disease II and Behcets disease A doctor can usually diagnose a canker sore based on a physical examination

Interestingly, compound 1 is destroyed by ascorbate oxidase (a prominent cell wall localised enzyme) so may have an ene diol group [96]

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As an initiator of the inflammatory cascade, IL-1 induces IL-6 production, thereby amplifying inflammation through T-helper 1 (Th1) and T-helper 17 (Th17) immune responses