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Due to insufficient blood supply, rapidly growing tumors in vivo are often hypoxic, and it is conceivable that this could enhance the therapeutic efficacy of APR-246, both in wild type and mutant TP53-carrying tumors

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Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C et al

Specifically, peptides and proteins that have been denatured or degraded can lead to adverse patient reactions such as undesired immune responses